Alzheimer's - Looking beyond plaques

Looking Beyond FDA Warning Letters to Explore Unforeseen Trouble Spots in eDTCA: A Response to Recent Commentaries

Carotid stenosis: looking beyond the lumen with ultrasound.

Carotid Stenosis: Looking Beyond the Lumen With Ultrasound To the Editor: We read with great interest the article by Wasserman et al.1 It represents an excellent review on the importance of carotid wall–imaging in decision-making in contemporary vascular neurology. The authors are to be congratulated for the excellent presentation of their case and for their keen comments. Unfortunately, MRI of...

Alzheimer's disease: is a vaccine possible?

The cause of Alzheimer's disease is still unknown, but the disease is distinctively characterized by the accumulation of β-amyloid plaques and neurofibrillary tangles in the brain. These features have become the primary focus of much of the research looking for new treatments for the disease, including immunotherapy and vaccines targeting β-amyloid in the brain. Adverse effects observed in a cl...

Communication Strategies Revisited: Looking beyond Interactional and Psycholinguistic Perspectives

Second language (L2) communication strategies (CSs) have traditionally been dealt with through either interactional or psychological perspectives. However, this paper is a critical attempt to question the status of the particular kinds of psycholinguistic and interactional approaches that currently dominate the field of second language acquisition (SLA). In this way, it expands the significance...

Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum

Genetic variations in the vacuolar protein sorting 10 protein (Vps10p) family have been linked to Alzheimer's disease (AD). Here we demonstrate deposition of fragments from the Vps10p member sortilin at senile plaques (SPs) in aged and AD human cerebrum. Sortilin changes were characterized in postmortem brains with antibodies against the extracellular and intracellular C-terminal domains. The t...